The "company" answer from ASUS is that the keys are easier to see in low light. If you are in such a situation, orienting from the 1 and 6 key makes it easier to know where you are, much like the small bumps on the "f" and "j" keys on a standard QWERTY board.
Some folks have noted that holding CTRL and pushing the 1 and 6 together has opened their homepage in Firefox. A couple have found CTRL and 1 to flip the screen orientation 90 degrees (why, I have no idea).
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ASUS EEE 900 16GB SSD, Peppermint One
ASUS EEE 1005PEB, Kubuntu 10.10/Windows 7 Starter
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